Article 10318

Title of the article

A STUDY OF THE CONTENT OF DIFFERENT PHENOTYPES OF NATURAL
KILLERS IN PATIENTS WITH PSORIASIS 

Authors

Sherstennikova Aleksandra Konstantinovna, Associate professor, sub-department of normal physiology, Northern State Medical University (51 Troitskiy avenue, Arkhangelsk, Russia), E-mail: a.sherstennikova@yandex.ru
Kashutin Sergey Leonidovich, Doctor of medical sciences, professor, head of sub-department of skin and venereal diseases, Northern State Medical University (51 Troitskiy avenue, Arkhangelsk, Russia), E-mail: sergeycash@yandex.ru
Neklyudova Viktoriya Sergeevna, Assistant, sub-department of skin and venereal diseases, Northern State Medical University (51 Troitskiy avenue, Arkhangelsk, Russia), E-mail: viknek999@yandex.ru
Kalmin Oleg Vital'evich, Doctor of medical sciences, professor, head of sub-department of human anatomy, Medical Institute, Penza State University (40 Krasnaya street, Penza, Russia), E-mail: ovkalmin@gmail.com
Shutskiy Nikita Alekseevich, Laboratory researcher, Central Research Laboratory, Northern State Medical University (51 Troitskiy avenue, Arkhangelsk, Russia), E-mail: nikitashutskijj@rambler.ru
Shagrov Leonid Leonidovich, Research assistant, Central Research Laboratory, Northern State Medical University (51 Troitskiy avenue, Arkhangelsk, Russia), E-mail: leonidshagrov@mail.ru 

Index UDK

616.5 

DOI

10.21685/2072-3032-2018-3-10 

Abstract

Background. Dates about the content of natural killers in psoriasis are important for understanding the processes of their migration to the lesion. The aim of the work was to study the content of various phenotypes of natural killers in patients with psoriasis.
Materials and methods. Clinico-immunological examination of 82 patients with vulgar and exudative forms of psoriasis in the progressing and stationary stage (39 women and 43 men) aged 20 to 60 years was carried out. As a control group, 50 practically healthy people (of them 28 women and 22 men) who did not have acute or exacerbation of chronic diseases were examined at the time of the examination. The concentration of lymphocytes containing the molecules of L-selectin (CD62L), ICAM-1 (CD54), LFA-1 (CD11a), LFA-3 (CD58), PECAM-1 (CD31), as well as phenotypes of lymphocytes with the phenotypes CD56 + CD16-, CD56 + CD16 +, CD56-CD16 +.
Results. In the conditions of psoriasis, a noticeable decrease in the absolute number of lymphocytes bearing the LFA-1 and PECAM-1 molecules participating in the «strong adhesion» and «transmigration» stages is recorded. Differences in the contents of CD56 + CD16, CD56-CD16 + and CD56 + CD16 +, as well as in concentrations of lymphocytes with the molecules of L-selectin, LFA-3 and ICAM-1, were not revealed. However, the conducted correlation analysis showed statistically significant correlations.
Conclusions. The absence of differences in the content of NK cells in patients with psoriasis is a compensatory manifestation of enhanced maturation in the red bone marrow in response to active migration to the lesion, which ultimately provides the required level of NK cells. 

Key words

psoriasis, natural killers

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Дата обновления: 26.03.2019 14:03